Glucose Absorption in Gestational Diabetes Mellitus During an Oral Glucose Tolerance Test

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Glucose Absorption in Gestational Diabetes Mellitus During an Oral Glucose Tolerance Test

OBJECTIVE Women with gestational diabetes mellitus (GDM) show reduced insulin sensitivity and markedly elevated glucose excursions. After delivery, GDM mostly reverts to normal glucose tolerance (NGT), although leaving an increased risk of type 2 diabetes. Because gastrointestinal function changes during pregnancy causing vomiting, constipation, or reduced motility, we thought that gut glucose ...

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Normal Glucose Tolerance and Gestational Diabetes Mellitus

RESEARCH DESIGN AND METHODS — After 100-g 3-h OGTTs, 4,053 pregnant women were classified as having GDM, OAV, or normal glucose tolerance (NGT). Those with OAV were subdivided into three subgroups: fasting hyperglycemia (one abnormal value at fasting during an OGTT), 1-h hyperglycemia (one abnormal value at 1 h during an OGTT [1h-OAV]), or 2or 3-h hyperglycemia (one abnormal value at 2 or 3 h d...

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Variants of Oral Glucose Tolerance Test (ogtt) Curve in Gestational Diabetes Mellitus (gdm)

Objective: Gestational diabetes mellitus is defined as “carbohydrate intolerance resulting in hyperglycemia of variable severity with onset or first recognition during pregnancy, whether or not insulin is used and regardless of whether diabetes persists after pregnancy. There is evidence that asymptomatic hyperglycemia during pregnancy leads to important morbidity in the mother and foetus. Henc...

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Prediction of Glucose Tolerance without an Oral Glucose Tolerance Test

Introduction Impaired glucose tolerance (IGT) is diagnosed by a standardized oral glucose tolerance test (OGTT). However, the OGTT is laborious, and when not performed, glucose tolerance cannot be determined from fasting samples retrospectively. We tested if glucose tolerance status is reasonably predictable from a combination of demographic, anthropometric, and laboratory data assessed at one ...

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Improvement of oral glucose tolerance in gestational diabetes by pyridoxine.

Fourteen pregnant women were shown by the oral glucose tolerance test to have gestational diabetes. In 13 an increased urinary xanthurenic-acid excretion after an oral load of L-tryptophan indicated a relative pyridoxine deficiency. All patients were treated with vitamin B6 (pyridoxine) 100 mg/day for 14 days by mouth, after which the pyridoxine deficiency disappeared and the oral glucose toler...

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ژورنال

عنوان ژورنال: Diabetes Care

سال: 2011

ISSN: 0149-5992,1935-5548

DOI: 10.2337/dc10-2266